Alzheimer's Disease and Down Syndrome Rodent Models Exhibit Audiogenic Seizures
نویسندگان
چکیده
منابع مشابه
Alzheimer's disease and Down syndrome rodent models exhibit audiogenic seizures.
Amyloid-beta protein precursor (AbetaPP) is overexpressed in Alzheimer's disease (AD), Down syndrome (DS), autism, and fragile X syndrome. Seizures are a common phenotype in all of these neurological disorders, yet the underlying molecular mechanism(s) of seizure induction and propagation remain largely unknown. We demonstrate that AD (Tg2576) and DS (Ts65Dn) mice exhibit audiogenic seizures, w...
متن کاملRodent models in Down syndrome research: impact and future opportunities
Down syndrome is caused by trisomy of chromosome 21. To date, a multiplicity of mouse models with Down-syndrome-related features has been developed to understand this complex human chromosomal disorder. These mouse models have been important for determining genotype-phenotype relationships and identification of dosage-sensitive genes involved in the pathophysiology of the condition, and in expl...
متن کاملAudiogenic reflex seizures in cats.
OBJECTIVES This study aimed to characterise feline audiogenic reflex seizures (FARS). METHODS An online questionnaire was developed to capture information from owners with cats suffering from FARS. This was collated with the medical records from the primary veterinarian. Ninety-six cats were included. RESULTS Myoclonic seizures were one of the cardinal signs of this syndrome (90/96), freque...
متن کاملGenetic dissection of susceptibility to audiogenic seizures in inbred mice.
Mice of some inbred strains, such as 21-day-old DBA/2J mice, have generalized convulsions when exposed to intense auditory stimulation. Analysis of susceptibility to audiogenic seizures in BXD recombinant inbred strains has demonstrated the influence of at least three loci. One locus, Asp-1, is located on chromosome 12 between Ah and D12Nyu1; another locus, Asp-2, is on chromosome 4, tightly li...
متن کاملDown Syndrome and Alzheimer’s Disease
Alzheimer’s disease (AD) is a prolonged, progressive, and incurable dementia that affects an individual, cognitively, functionally and emotionally. A person is unable to think coherently, use reason or logic, language, or may be disoriented to space, time and self. The individual may be unable to start or complete an activity thus becoming easily distracted and frustrated at this loss of purpos...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Alzheimer's Disease
سال: 2010
ISSN: 1875-8908,1387-2877
DOI: 10.3233/jad-2010-100087